A groundbreaking study presented at the American Heart Association’s Vascular Discovery 2025 Scientific Sessions has uncovered potentially significant links between micronanoplastics and carotid artery plaque, revealing concentrations of these microscopic plastic particles that could have profound implications for cardiovascular health.
Researchers discovered that carotid artery plaque contains substantially higher levels of micronanoplastics compared to healthy arterial tissue. The study found micronanoplastic concentrations 16 times higher in asymptomatic plaque and 51 times higher in plaque from individuals who experienced stroke, mini-stroke, or temporary vision loss.
Lead study author Dr. Ross Clark from the University of New Mexico emphasized that these tiny plastic particles, often invisible to the naked eye, originate primarily from food and water sources rather than just plastic consumer products. Micronanoplastics, defined as plastic particles less than 5 millimeters and potentially as small as 1,000 nanometers, can easily penetrate cells and tissues.
The research analyzed 48 carotid artery samples from adults, comparing plaque from individuals with varying cardiovascular conditions. While the study cannot definitively prove micronanoplastics cause arterial symptoms, it suggests a complex interaction between these particles and biological processes.
Notably, the research found differences in gene activity among plaque-stabilizing cells and inflammatory markers when comparing samples with high and low micronanoplastic levels. Dr. Clark cautioned that the biological effects are more nuanced than simply triggering immediate inflammation.
Dr. Karen L. Furie from Brown University noted the study’s significance, stating that micronanoplastic exposure has not previously been considered a modifiable stroke risk factor. This research opens new avenues for understanding potential preventative strategies in cardiovascular health.
Researchers acknowledged study limitations, including potential measurement challenges and the need for further investigation. The preliminary findings underscore the importance of continued research into environmental contaminants and their potential health impacts.
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