Three research teams from Augusta University, Massachusetts General Hospital, and The Ohio State University will lead a comprehensive $15 million project exploring how cardiovascular and kidney disease risk factors uniquely affect women. The American Heart Association’s Strategically Focused Research Network will examine the complex interactions between cardiovascular, kidney, and metabolic health in women across different life stages.
Cardiovascular-kidney-metabolic (CKM) syndrome describes the combined health effects of heart disease, kidney disease, diabetes, and obesity. Approximately one in three U.S. adults experiences at least three components of this syndrome, including high blood pressure, abnormal cholesterol, high blood glucose, impaired kidney function, and excess body weight.
Each research center will focus on distinct aspects of women’s health. Augusta University will investigate the lifelong effects of obesity, examining how weight gain differs between males and females and exploring potential pregnancy complications. Massachusetts General Hospital will study how pregnancy history and female-specific risk factors might provide insights into future heart disease risks. The Ohio State University will implement the Beyond One Size Fits All (B-FIT) initiative, exploring personalized approaches to women’s cardiovascular health.
A critical component of the research is addressing the historical underrepresentation of women in clinical studies. By examining biological factors associated with life cycles like menopause and pregnancy, researchers hope to develop more targeted preventive strategies and therapeutic approaches.
The project also emphasizes diversity in clinical research, with each center collaborating with academic institutions serving underrepresented populations. This approach aims to generate more comprehensive and inclusive health insights that can potentially benefit women from diverse backgrounds.
The American Heart Association’s investment in this research is part of its broader commitment to cardiovascular health. The organization has previously funded nearly $5.9 billion in cardiovascular and brain health research, making it the largest non-government supporter of such studies in the United States.
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